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Clomiphine Citrate
 
Background

Clomiphine citrate has been used for ovulation induction for many years. It acts by functioning as an antiestrogen, blocking the normal feedback response between the ovary and the hypothalmic pituitary axis. By blocking the estrogen receptor the pituitary gland receives less estrogen being present and releases an increased amount of FSH to stimulate the ovary. This results in the recruitment and continued development of an oocyte and eventual ovulation.

The antiestrogenic effect of Clomiphine can also affect the priming effect of estrogen on the endometrial lining as well as the production of cervical mucous. The ultimate effect on these target organs is usually a balance between the increased estrogen produced as a result of ovarian stimulation and the antiestrogenic effect of the Clomiphine.

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